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NMN Supplement [2023-Updated] – Buyer Guide, Reviews, Science & Everything Else You Need to Know

Is there a fountain of youth? Well, science is now bringing us closer to understanding the complex mechanisms of aging and how to potentially slow it down. Nicotinamide mononucleotide, or NMN, has emerged as a promising candidate in the anti-aging arena. Could the NMN supplement offer a solution to aging? Let’s talk about it – today we’re taking an in-depth look into the science, reviews, and essential information you need to know before integrating this supplement into your health regimen.

We will talk about:

  • How NAD+ and its precursor NMN can help you feel younger and stronger
  • Why even supplement NMN (since its a precursor)
  • What the best option for supplementing NMN is – including real user reviews and expert overview of the science
  • … and much more!

Whether you’re a science enthusiast or someone seeking to improve your health as you age, this guide is your ultimate resource for understanding NMN in 2023. So, let’s jump straight in:

What Do NMN and NAD+ Have to Do With Aging?

Amongst the myriad of biological elements linked to aging, an element called NAD+ stands out. This coenzyme is vital for cellular energy production and repair but sadly diminishes as we age.

How NAD+ Works in the Body

NAD+ is synthesized and regulated in the body through a complex network. Vitamin B3 serves as a building block for NAD+, and NMN is known as an efficient precursor to NAD+. NMN, found in foods like avocados and broccoli, is primarily synthesized from vitamin B3 in mammals. Enzymes for producing NMN levels decline with age – and your weight status seems to matter too, as fatty tissue plays a part in NAD+ biosynthesis.

Recently, a transporter was found that can directly transport NMN into cells. This transporter, called Slc12a8, is especially active in the small intestine. This leads researchers to speculate that the gut microbiome might be involved in producing NMN.

NMN, Aging, and NAD+ Levels

As we age, NMN levels decrease and the body’s ability to convert NMN to NAD+ is compromised. NAD+ is vital for various physiological processes and a decline in its levels is associated with aging.

Studies on mice have shown that NMN has numerous health and anti-aging benefits. It has been effective in suppressing age-associated weight gain, improving energy metabolism, insulin sensitivity, eye function, and mitochondrial metabolism. Even better, it has shown potential in preventing changes in gene expression due to aging. We have also seen that NMN improved heart health and reduced cognitive decline in mouse models. And it also appears to be efficient in combating ‘inflammaging’ – the increase in inflammation associated with aging.

Bottom line: NMN shows varied and comprehensive effects on aging. It seems to affect both lifespan and health span (years you live without disease), making it one of the most promising supplements to help you live a longer healthier life.

Can You Supplement NMN efficiently?

NMN is stable in water and is rapidly absorbed by the body. In mice studies, oral administration led to a sharp increase in plasma NMN levels in just a few minutes. But what about safety? Well, that has been tested, too – long-term oral administration of NMN was found to be safe and well-tolerated.

So, in short, yes, NMN supplements are a great addition to your anti-aging routine. But not all of them were created equal. Here are the top products to try today

Expert’s Choice: Ascuoli Sublingual 500mg NMN + Trans-Resveratrol

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For those seeking a high-quality NMN supplement, the Ascuoli Sublingual NMN stands out as the best option (my opinion, anyway, but it’s shared by plenty of other experts). This product is not only packed with 500mg of NMN, but it also has Trans-Resveratrol for enhanced absorption and black pepper extract for additional health benefits. Let’s delve into the key features and benefits of this promising supplement.

What’s In the Supplement? Dosage, Combination, How Long It Lasts

Ascuoli offers an impressive formulation of 500mg NMN, 400mg Trans-Resveratrol, and 50mg Black Pepper Extract per lozenge. With 120 tablets in each bottle and a total of 900mg of active ingredients per lozenge, this supplement provides a generous four-month supply.

Enhanced Bioavailability

What sets this product apart is its sublingual delivery in lozenge form. This allows NMN and Trans-Resveratrol to be absorbed directly into the blood vessels in the mouth and under the tongue. This direct absorption bypasses the digestive system and can greatly increase the bioavailability of NMN and Trans-Resveratrol, enhancing their effects on the body.

User Feedback and Performance

The Ascuoli Sublingual NMN has garnered promising reviews on Amazon, attesting to its efficacy. My favorite? This person with cerebral palsy mentioned significant improvements in mental clarity and gym performance upon taking this supplement. Check out his full (super promising) review:

Ascoli NMN supplement review

Considering cerebral palsy’s seriousness, this is some serious promise. But, we saw multiple other users have echoed improvements in exercise performance and stamina. The product got a solid 4.4/5 on Amazon and is attracting a lot of attention.


Ascuoli Sublingual NMN 500mg + Trans-Resveratrol 400mg Supplement is a high-caliber choice for anyone looking to incorporate NMN into their health regimen. The thoughtful formulation, sublingual delivery for increased bioavailability, and overwhelmingly positive user feedback make this product a standout option.

People’s Favorite: Tru Niagen NAD+ Boosting Supplement

Tru Niagen Amazon screenshot

Looking for a cost-effective way to boost your NAD+ levels and enhance overall health? Tru Niagen, a patented form of Nicotinamide Riboside (NR), has earned its place as the people’s favorite. Although it’s not our top choice due to its NR formulation, as opposed to NMN, it’s still a powerful supplement known for its effectiveness in boosting NAD+. Let’s dive into its main features and benefits.

Efficient and Affordable

Tru Niagen stands out due to its patented NR, which efficiently boosts NAD+. This supplement also shines for its affordability. At roughly $0.66 per tablet, it offers a budget-friendly option for those who want to enhance their health without breaking the bank.

User Feedback and Performance

The effectiveness of Tru Niagen is backed by solid user feedback. A long-term user shared that their health markers, as measured through blood work, have either remained the same or improved over the four years they’ve been taking the supplement. This includes improvements in markers that had been trending outside the ideal range, such as good cholesterol and platelets.

Tru Niagen promising review


Despite not being an NMN supplement, Tru Niagen’s patented NR formulation and its efficient NAD+ boosting properties have made it a favorite among users. The affordable pricing and positive feedback, particularly around improved health markers and increased mental clarity, make it an attractive choice for those looking to supplement their NAD+ levels and enhance overall wellbeing.

Increasing NAD+ Levels Naturally

While supplements like NMN and NR are effective ways to boost NAD+ levels, incorporating natural methods into your lifestyle can also seriously change your aging, improve your athletic performance and generally help you feel in top shape. Here are some of my favorite ways to elevate NAD+ levels naturally:

1. Eat NAD+ Rich Foods

Certain foods are known to be rich in NAD+ precursors, which can help boost NAD+ levels. Include the following in your diet:

  • Dairy Products: Milk contains nicotinamide riboside, a precursor to NAD+.
  • Fermented Foods: Foods like sauerkraut, kimchi, and yogurt are believed to increase NAD+ levels.
  • Lean Meats: Chicken, turkey, and red meat contain nicotinamide, which can be converted to NAD+.
  • Fish: Fish like tuna and salmon are rich in niacin, another NAD+ precursor.
  • Whole Grains and Seeds: Containing niacin, these can also boost NAD+ production.

2. Move Your Body

Regular physical activity has been shown to increase NAD+ levels. Exercise stimulates the production of certain enzymes that are crucial for NAD+ synthesis.

  • Aerobic Exercise: Get your blood pumping like jogging, swimming, or cycling can be beneficial. Not only does it boost NAD+ but it also helps protect your heart and overall health in many other ways.
  • Resistance Training: Weightlifting and bodyweight exercises can also positively affect NAD+ levels. The current recommendations are that you do resistance training at least twice a week – try it for a couple of months and you’ll feel the difference.

3. Cut Your Calories

Reducing your calorie intake can stimulate the body to produce more NAD+. Caloric restriction is thought to trigger a survival response, making cells more efficient, which in turn increases NAD+ production.

Intermittent Fasting is an interesting and pretty efficient approach here. Practicing intermittent fasting or eating within a certain window of time can mimic the effects of caloric restriction without drastically reducing food intake.

4. Reduce Stress

Chronic stress can deplete NAD+ levels. Engaging in stress-reduction techniques can be great here – here are some of the most popular (and simplest) ones:

  • Meditation and Mindfulness: Practicing meditation or mindfulness can help in managing stress.
  • Yoga and Breathing Exercises: These practices have been shown to reduce stress levels, which may indirectly support NAD+ production.

5. Get Enough Sleep

Sleep is essential for the body’s recovery and repair processes. High-quality sleep supports the body’s natural ability to produce NAD+, so here is how to achieve that

  • Establishing a Sleep Routine: Go to bed and wake up at the same time every day.
  • Creating a Comfortable Sleep Environment: Make sure your bedroom is conducive to sleep by controlling light and noise levels and ensuring a comfortable mattress and pillows.

Final Thoughts

Incorporating a combination of a balanced diet, regular exercise, caloric restriction, stress management, and proper sleep into your lifestyle can support the natural production of NAD+ in your body. These natural methods not only contribute to boosting NAD+ levels but also promote overall health and wellbeing.

But, if you want to take it up a notch, an NMN supplement can supercharge your body’s ability to perform and it can even fight aging. As long as you’re buying your supplement from a reputable brand (and double-checking with your doctor that it’s safe for you!), you are in the clear. Check out some of our favorite options today!

Does NMN actually work?

Yes, and the science is piling up. There is growing evidence that NMN can effectively raise NAD+ levels in the body. Animal models show promising results regarding the anti-aging effects and improvement in energy metabolism. But, we still need larger human studies are needed to firmly establish the efficacy and safety of NMN supplements for long-term use.

Is NMN just vitamin B?

No, NMN is not just vitamin B but it’s made from B3. NMN stands for nicotinamide mononucleotide, which is a derivative of niacin, a form of vitamin B3. NMN is a precursor to NAD+, meaning it’s one of the compounds that the body can use to create NAD+. While NMN is related to vitamin B3, it’s not the same thing.

Who should take NMN supplements?

If you’re looking to age healthier (and potentially slower), NMN can be right for you. It’s also a great option for boosting energy levels and metabolic functions. However, it is highly recommended to consult a healthcare provider before beginning any supplement regimen – and it’s a must if you have underlying medical conditions.

Why is NMN so expensive?

NMN is expensive mostly because of how complex production and purification are. Producing NMN in a form that is bioavailable and effective for human consumption requires sophisticated processing techniques. Plus, as NMN is still an emerging supplement, the demand is high, and the production scale is relatively low – this also drives prices up.

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